As the market shifts to a more defensive tone, Merck’s (MRK) recent breakout is a constructive signal that suggests potential institutional accumulation and further upside. With a diversified late-stage pipeline, MRK stands out as one of the most attractively valued large-cap pharmaceutical companies. The combination of raised guidance, favorable sector positioning, and consistent demand for its flagship oncology franchise positions MRK for continued upside. Trade timing & outlook MRK has broken out above $85 resistance, which now serves as new support, providing an optimal risk/reward and timing to seek bullish exposure currently. Relative strength versus both the S & P 500 and its healthcare peers confirms institutional accumulation. We are targeting $90 initially with a $100 extended target above. Fundamentals Merck continues to deliver resilient financial performance and raised guidance for 2025, reflecting confidence in its long-term growth trajectory. Strong demand for oncology products like Keytruda and contributions from newer launches bolster revenue. The stock trades at a meaningful discount to peers on forward multiples, despite superior growth and profitability. Forward PE ratio : 9.4x vs. industry average 12.3x Expected EPS growth : 11.4% vs. industry average 6.5% Expected revenue growth : 4.0% vs. industry average 3.6% Net margins : 25.8% vs. industry average 16.1% Bullish thesis Resilient financials : Q2 2025 sales of $15.8B with raised EPS guidance reflect increasing demand and operational efficiency. Diversified growth pipeline : Over 50 programs in development, with more than 30 in Phase 3, covering oncology, vaccines, cardiometabolic, and immunology. Analysts highlight up to 20 potential blockbusters with $50B combined sales opportunity. Strategic expansion : Pending $10B Verona Pharma acquisition secures exposure to newly approved lung therapies, broadening the portfolio. Options strategy To capture this breakout and manage elevated IV, we’re using a call debit spread straddling the current price by buying the Oct $80/90 Call Vertical @ $5.14 Debit. This entails: Buying the Oct 17, 2025 $80 Call @ $6.65 Selling Oct 17, 2025 $90 Call @ $1.51 Max reward : $486 per contract if MRK is above $90 at expiry Max risk: $514 per contract if MRK is below $80 at expiry View this trade in OptionsPlay for updated pricing . Summary Merck presents a compelling mix of technical strength, undervalued fundamentals, and robust growth prospects. Its recent breakout signals upside ahead, supported by resilient sales, positive analyst outlooks, and a deep late-stage pipeline. This call debit spread offers you a defined-risk way to participate in further gains while accounting for elevated options implied volatility. DISCLOSURES: None. All opinions expressed by the CNBC Pro contributors are solely their opinions and do not reflect the opinions of CNBC, NBC UNIVERSAL, their parent company or affiliates, and may have been previously disseminated by them on television, radio, internet or another medium. THE ABOVE CONTENT IS SUBJECT TO OUR TERMS AND CONDITIONS AND PRIVACY POLICY . THIS CONTENT IS PROVIDED FOR INFORMATIONAL PURPOSES ONLY AND DOES NOT CONSITUTE FINANCIAL, INVESTMENT, TAX OR LEGAL ADVICE OR A RECOMMENDATION TO BUY ANY SECURITY OR OTHER FINANCIAL ASSET. THE CONTENT IS GENERAL IN NATURE AND DOES NOT REFLECT ANY INDIVIDUAL’S UNIQUE PERSONAL CIRCUMSTANCES. THE ABOVE CONTENT MIGHT NOT BE SUITABLE FOR YOUR PARTICULAR CIRCUMSTANCES. BEFORE MAKING ANY FINANCIAL DECISIONS, YOU SHOULD STRONGLY CONSIDER SEEKING ADVICE FROM YOUR OWN FINANCIAL OR INVESTMENT ADVISOR. Click here for the full disclaimer.