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LONDON — European stocks opened lower on Thursday, as investors reacted to another flurry of corporate earnings.

The pan-European Stoxx 600 was 0.3% lower 20 minutes into the session, with most sectors and major bourses in negative territory. France’s CAC 40 led losses among major regional indexes, with a decline of 0.7%.

It’s a busy day for earnings with third-quarter reports due from a slew of regional companies.

AstraZeneca held its guidance steady on Thursday morning, after reporting better-than-expected third-quarter revenues and profit. Total revenue, which jumped 10% year-on-year in the third quarter on a constant currency basis, is expected to rise by a high single-digit percentage this year, while core earnings per share are forecast to jump by a low double-digit percentage.

Shares were 0.7% higher shortly after the opening bell.

Speaking to CNBC’s “Squawk Box Europe” on Thursday morning, AstraZeneca CEO Pascal Soriot said the company had decided to keep its guidance unchanged as it was still grappling with headwinds in China and Latin America.

“We have a range in our guidance; we could end up in the top end of the range. We decided to be cautious and potentially overdeliver if everything goes well,” he said.  

Soriot also touched on relations with Trump in Thursday’s interview with CNBC.

“President Trump wants to rebalance the cost and risk of innovation in our industry … he wants to make sure that countries pay their fair share of developing medicines that can save lives,” he said. “We understood this and we agree with that, so we’ve been pursuing a strategy of investing in the U.S. so we can manufacture all our products in the U.S., we’re investing in R&D in the United States, and we also agree the cost of innovation and the risk associated with it should be rebalanced across wealthy countries.”

German logistics firm DHL also beat estimates in the third quarter, but CEO Tobias Meyer told CNBC’s “Squawk Box Europe” that the company had seen a significant decline in U.S. trading volumes.

DHL shares were 5.7% higher in early trade.

Meanwhile, shares of German lender CommerzBank fell 1.7% after the firm reported a surprise 7.9% year-on-year fall in net profit for the third quarter, coming in at 591 million euro ($680 million).

CEO Bettina Orlopp told CNBC’s Annette Weisbach that the profit miss was down to a booked tax effect. “We have a cost income ratio of 56%, which is three percentage points lower than last year’s number,” she said. The bank also incurred 553 million euros of restructuring costs earlier in the year.

Despite this, the bank said it now expects higher net interest income. It raised its full-year guidance to 8.2 billion euros, up from 8 billion euros.

Central bank decisions are due from Norway and the U.K. on Thursday, with the Bank of England seen as likely to hold its key interest rate at 4% while policymakers await the government’s fiscal plans in the Autumn Budget on Nov.26.

Taking a glance at global markets overnight, Asia-Pacific markets rose, tracking Wall Street gains after AMD’s third-quarter earnings beat lifted artificial intelligence stocks.

Meanwhile, U.S. stock futures were slightly lower overnight as investors grew less wary of eye-watering AI valuations and were encouraged by the tone of a Supreme Court hearing on President Donald Trump’s sweeping tariffs.

Investors increasingly expect the Supreme Court to rule against the Trump administration’s aggressive trade policy after high court justices on Wednesday expressed some skepticism about the trade taxes’ legality at a hearing in Washington. The potential ruling would trigger a rollback of the president’s tariffs, likely pushing stocks higher.

— CNBC’s Liz Napolitano contributed reporting to this story.